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Protective effect of tanshinone II A on signal transduction system protein kinase B in rats with myocardial

Enyuan TU MD, Yongjun PAN MM, Kang ZHENG MM, Zhaohua WANG MD, Qiansheng LIANG MD, Guangtian YANG MD,

Frontiers of Medicine 2009, Volume 3, Issue 4,   Pages 431-436 doi: 10.1007/s11684-009-0088-4

Abstract: The effects of tanshinone II A on cell signal transduction system protein kinase B in rats with myocardialdiameter (MFD) was examined by Hematoxylin-Eosin (HE) staining, and the contents of phosphorylated proteinkinase B (p-Akt) and p-Gsk3β in myocardium were assayed by Western blot.

Keywords： tanshinone II A     myocardial hypertrophy     rat     protein kinase B     abdominal aorta coarctation    

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Inhibition of protein kinase B by Palmitate in the insulin signaling of HepG2 cells and the preventive

XIA Yanzhi, WAN Xuedong, DUAN Qiuhong, HE Shansu, WANG Ximing

Frontiers of Medicine 2007, Volume 1, Issue 2,   Pages 200-206 doi: 10.1007/s11684-007-0038-y

Abstract: Elevated plasma levels of free fatty acids (FFAs) may contribute to insulin resistance (IR) that is characteristic of type 2 diabetes mellitus. In this study, we investigated the effects of two fatty acids, palmitate (PA) and arach

Keywords： palmitate     characteristic     study     plasma     resistance    

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Mechanisms of connective tissue formation and blocks of mitogen activated protein kinase

Irina A SHURYGINA, Michael G SHURYGIN, Nataliya I AYUSHINOVA, Galina B GRANINA, Nikolay V ZELENIN

Frontiers of Chemical Science and Engineering 2012, Volume 6, Issue 2,   Pages 232-237 doi: 10.1007/s11705-012-1286-1

Abstract: groups of animals were examined respectively for inoculation of inhibitor of p38 MAPK (mitogen activated proteinkinase) SB 203580 and JNK inhibitor SP 600125, and a control.

Keywords： connective tissue     mitogen activated protein kinase (MAPK)     p38     JNK    

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The role of protein kinase C epsilon in neural signal transduction and neurogenic diseases

Yuan CHEN, Qi TIAN

Frontiers of Medicine 2011, Volume 5, Issue 1,   Pages 70-76 doi: 10.1007/s11684-011-0119-9

Abstract:

Protein kinase C epsilon (PKC ?) is one of major isoforms in novel PKC family.

Keywords： protein kinase C ?     signal transduction     neurogenic disease    

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Effect of inhibiting tyrosine kinase Src expression on protein phosphatase 2A and tau phosphorylation

LIU Rong, ZENG Ji, ZHOU Xinwen, WANG Jianzhi, PEI Jinjing

Frontiers of Medicine 2008, Volume 2, Issue 3,   Pages 235-238 doi: 10.1007/s11684-008-0044-8

Abstract: The aim of this study is to investigate the effect of tyrosine kinase Src on Tyrosine 307(Y307) phosphorylation, protein phosphatase 2A (PP2A) activity, and on tau phosphorylation.siRNA was transfected into cultured mouse neuroblastoma N2a cells to inhibit the expression of Src proteinTwelve hours after siRNA transfection, the protein level of Src was dramatically decreased, with decreasedHowever, the total PP2A protein level was also decreased, together with a decreased PP2A activity.

Keywords： hyperphosphorylation     PP2A activity     cellular regulation     siRNA     siRNA transfection    

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Mitogen-activated protein kinase pathway inhibitors: inhibitors for diseases?

Xu WANG MS, Xiao-Wei GONG MD, PhD, Yong JIANG MD, PhD, Yu-Hua LI PhD,

Frontiers of Medicine 2010, Volume 4, Issue 1,   Pages 46-53 doi: 10.1007/s11684-010-0010-0

Abstract: Mitogen-activated protein kinase (MAPK) signaling pathway, one of the most important signaling pathwaysSo far, inhibitors specifically against each subfamilies of MAP kinase have been developed, while moreMost of the kinase inhibitors exert their functions in an ATP-competitive way or a non-ATP-competitiveinhibitors and their therapeutic roles in the treatment of diseases are helpful for the illumination of MAP kinase

Keywords： mitogen-activated protein kinase     drug target     inhibitor     signal transduction     disease    

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effects of ketamine with increased levels of brain-derived neurotrophic factor and tropomyosin-related kinaseB in rat hippocampus

Chun Yang, Xiaomin Li, Nan Wang, Shixia Xu, Jianjun Yang, Zhiqiang Zhou

Frontiers of Medicine 2012, Volume 6, Issue 4,   Pages 411-415 doi: 10.1007/s11684-012-0226-2

Abstract: Brain-derived neurotrophic factor (BDNF) is an important biomarker for mood disorders and tropomyosin-related kinaseB (TrkB) is a high affinity catalytic receptor for BDNF.

Keywords： tramadol     ketamine     antidepressant     brain-derived neurotrophic factor     tropomyosin-related kinase B    

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Involvement of p38 mitogen-activated protein kinase in the regulation of platelet-derived growth factor

GONG Xiaowei, WEI Jie, LI Yusheng, CHENG Weiwei, DENG Peng, JIANG Yong

Frontiers of Medicine 2007, Volume 1, Issue 3,   Pages 248-252 doi: 10.1007/s11684-007-0047-x

Abstract: The aim of this study was to investigate the role of p38 mitogen-activated protein kinase (MAPK) in cellmigration of NIH3T3 cells was significantly increased (〈0.001) compared to the control and p38 MAP kinase

Keywords： control     stimulation     mitogen-activated     growth factor     process    

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Valorisation of protein waste: An enzymatic approach to make commodity chemicals? ?

Madura B. A. Kumar, Yuan Gao, Wei Shen, Lizhong He

Frontiers of Chemical Science and Engineering 2015, Volume 9, Issue 3,   Pages 295-307 doi: 10.1007/s11705-015-1532-4

Abstract: Protein-rich waste is an abundantly available resource that is currently used mainly as animal feed andValorisation of protein waste to higher value products, particularly commodity chemicals such as precursorsenvironmentally-friendly compared to their chemical counterparts, promise sustainable processes for conversion of proteinThis review provides a general overview on valorisation of protein waste and then further summarisesthe use of enzymes in different stages of the valorisation process—protein extraction and hydrolysis,

Keywords： amino acids     protein waste     reactor     conversion     commodity chemicals     enzymes    

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Resistance to receptor tyrosine kinase inhibition in cancer: molecular mechanisms and therapeutic strategies

Peter B. Alexander,Xiao-Fan Wang

Frontiers of Medicine 2015, Volume 9, Issue 2,   Pages 134-138 doi: 10.1007/s11684-015-0396-9

Abstract: In this review, we discuss the main known mechanisms of resistance to receptor tyrosine kinase inhibitors

Keywords： targeted therapy     drug resistance     receptor tyrosine kinases     cancer    

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Loss of liver kinase B1 causes planar polarity defects in cochlear hair cells in mice

Yuqin Men,Aizhen Zhang,Liwen Zhang,Yecheng Jin,Zhishuo Wang,Jing Zhao,Xiaolin Yu,Jian Zhang,Jiangang Gao

Frontiers of Medicine 2016, Volume 10, Issue 4,   Pages 481-489 doi: 10.1007/s11684-016-0494-3

Abstract:

The tumor suppressor gene liver kinase B1 (LKB1), also called STK11, encodes a serine/threonine kinase

Keywords： LKB1     stereociliary bundles     kinocilium     planar cell polarity     hearing     mice    

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Mechanisms of insulin resistance in obesity

Jianping Ye

Frontiers of Medicine 2013, Volume 7, Issue 1,   Pages 14-24 doi: 10.1007/s11684-013-0262-6

Abstract: The energy surplus signal is mediated by ATP and sensed by adenosine monophosphate-activated proteinkinase (AMPK) signaling pathway.

Keywords： expenditure     inflammation     lipotoxicity     mitochondria     hyperinsulinemia     adenosine monophosphate-activated proteinkinase (AMPK)    

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Proteomics study of Mycoplasma pneumoniae pneumonia reveals the Fc fragment of the IgG-binding protein

Frontiers of Medicine 2022, Volume 16, Issue 3,   Pages 378-388 doi: 10.1007/s11684-021-0840-y

Abstract: The Fc fragment of the IgG-binding protein (FCGBP) was identified as the most promising indicator ofAmong them, a mechanistic target of rapamycin kinase (mTOR) inhibitor, which is a macrolide compound

Keywords： severe Mycoplasma pneumoniae pneumonia     children     proteomics     Fc fragment of the IgG-binding protein     mechanistic target of rapamycin kinase inhibitor    

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Dysregulation of β-catenin by hepatitis B virus X protein in HBV-infected human hepatocellular carcinomas

Lei CHEN, Liang HU, Liang LI, Yuan LIU, Qian-Qian TU, Yan-Xin CHANG, He-Xin YAN, Meng-Chao WU, Hong-Yang WANG,

Frontiers of Medicine 2010, Volume 4, Issue 4,   Pages 399-411 doi: 10.1007/s11684-010-0170-y

Abstract: in the development of hepatocellular carcinoma (HCC), β-catenin was correlated with hepatitis Bvirus (HBV) X gene encoded protein, which is essential for HBV infectivity and is a potential cofactorlevels of wild-type β-catenin and E-cadherin were decreased in HepG2 cells expressing hepatitis Bvirus X protein (HBx), accompanied by destabilization of adherens junction.Western blot showed that reduction of wild-type β-catenin expression involved degradation of the protein

Keywords： hepatocellular carcinoma     hepatitis B virus X protein     β     -catenin     cell adhesion     E-cadherin     transcriptional    

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Effects of phosphatidylinositol 3-kinase inhibitor on human cervical carcinoma cells

Yuan ZHANG MD , Xiaoyan ZHANG MM , Yanhui LI MM , Xuan DU MM , Zehua WANG MD, PhD , Hongbo WANG MD ,

Frontiers of Medicine 2009, Volume 3, Issue 3,   Pages 341-346 doi: 10.1007/s11684-009-0067-9

Abstract: Phosphatidylinositol 3-kinase (PI3K) is a crucial cell survival pathway implicated in tumorigenesis becauseLY294002, an inhibitor of PI3K in cervical cancer cells and the expression of FLICE-like inhibitory protein

Keywords： human cervical cancer cells     apoptosis     phosphatidylinositol 3-kinase (PI3K)/Akt     FLICE-like inhibitoryprotein    

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Title Author Date Type Operation

Protective effect of tanshinone II A on signal transduction system protein kinase B in rats with myocardial

Enyuan TU MD, Yongjun PAN MM, Kang ZHENG MM, Zhaohua WANG MD, Qiansheng LIANG MD, Guangtian YANG MD,

Journal Article

Inhibition of protein kinase B by Palmitate in the insulin signaling of HepG2 cells and the preventive

XIA Yanzhi, WAN Xuedong, DUAN Qiuhong, HE Shansu, WANG Ximing

Journal Article

Mechanisms of connective tissue formation and blocks of mitogen activated protein kinase

Irina A SHURYGINA, Michael G SHURYGIN, Nataliya I AYUSHINOVA, Galina B GRANINA, Nikolay V ZELENIN

Journal Article

The role of protein kinase C epsilon in neural signal transduction and neurogenic diseases

Yuan CHEN, Qi TIAN

Journal Article

Effect of inhibiting tyrosine kinase Src expression on protein phosphatase 2A and tau phosphorylation

LIU Rong, ZENG Ji, ZHOU Xinwen, WANG Jianzhi, PEI Jinjing

Journal Article

Mitogen-activated protein kinase pathway inhibitors: inhibitors for diseases?

Xu WANG MS, Xiao-Wei GONG MD, PhD, Yong JIANG MD, PhD, Yu-Hua LI PhD,

Journal Article

effects of ketamine with increased levels of brain-derived neurotrophic factor and tropomyosin-related kinaseB in rat hippocampus

Chun Yang, Xiaomin Li, Nan Wang, Shixia Xu, Jianjun Yang, Zhiqiang Zhou

Journal Article

Involvement of p38 mitogen-activated protein kinase in the regulation of platelet-derived growth factor

GONG Xiaowei, WEI Jie, LI Yusheng, CHENG Weiwei, DENG Peng, JIANG Yong

Journal Article

Valorisation of protein waste: An enzymatic approach to make commodity chemicals? ?

Madura B. A. Kumar, Yuan Gao, Wei Shen, Lizhong He

Journal Article

Resistance to receptor tyrosine kinase inhibition in cancer: molecular mechanisms and therapeutic strategies

Peter B. Alexander,Xiao-Fan Wang

Journal Article

Loss of liver kinase B1 causes planar polarity defects in cochlear hair cells in mice

Yuqin Men,Aizhen Zhang,Liwen Zhang,Yecheng Jin,Zhishuo Wang,Jing Zhao,Xiaolin Yu,Jian Zhang,Jiangang Gao

Journal Article

Mechanisms of insulin resistance in obesity

Jianping Ye

Journal Article

Proteomics study of Mycoplasma pneumoniae pneumonia reveals the Fc fragment of the IgG-binding protein

Journal Article

Dysregulation of β-catenin by hepatitis B virus X protein in HBV-infected human hepatocellular carcinomas

Lei CHEN, Liang HU, Liang LI, Yuan LIU, Qian-Qian TU, Yan-Xin CHANG, He-Xin YAN, Meng-Chao WU, Hong-Yang WANG,

Journal Article

Effects of phosphatidylinositol 3-kinase inhibitor on human cervical carcinoma cells

Yuan ZHANG MD , Xiaoyan ZHANG MM , Yanhui LI MM , Xuan DU MM , Zehua WANG MD, PhD , Hongbo WANG MD ,

Journal Article